Oxysterols and retinal degeneration

Retinal degeneration, characterised by the progressive death of retinal neurons, is most common cause visual impairment. Oxysterols are cholesterol derivatives produced via enzymatic and/or free radical oxidation that regulate homeostasis in retina. Preclinical and clinical studies have suggested a connection between oxysterols degeneration. Here, we summarise early recent work related to retina oxysterol-producing enzymes distribution We examine impact loss on pathology explore molecular mechanisms associated with toxic or protective roles individual different types conclude increased efforts better understand oxysterol-associated pathophysiology will help development effective degeneration therapies. LINKED ARTICLES This article part themed issue Oxysterols, Lifelong Health Therapeutics. To view other articles this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.16/issuetoc